I found a little tool on the net a while ago that will kill alot of the common ones...
"This tool removes Desktop Hijack malware: AdwarePunisher, AdwareSheriff, AlphaCleaner, Antispyware Soldier, AntiVermeans, AntiVermins, AntiVerminser, AntivirusGolden, AVGold, BraveSentry, MalwareWipe, MalwareWiped, MalwaresWipeds, MalwareWipePro, MalwareWiper, PestCapture, PestTrap, PSGuard, quicknavigate.com, Registry Cleaner, Security iGuard, Smitfraud, SpyAxe, SpyCrush, SpyDown, SpyFalcon, SpyGuard, SpyHeal, SpyHeals, SpyLocked, SpyMarshal, SpySheriff, SpySoldier, Spyware Vanisher, Spyware Soft Stop, SpywareLocked, SpywareQuake, SpywareKnight, SpywareSheriff, SpywareStrike, Startsearches.net, TitanShield Antispyware, Trust Cleaner, UpdateSearches.com, Virtual Maid, VirusBlast, VirusBurst, Win32.puper, WinHound, Brain Codec, DirectVideo, EliteCodec, eMedia Codec, FreeVideo, Gold Codec, HQ Codec, iCodecPack, iMediaCodec, Image ActiveX Object, IntCodec, iVideoCodec, JPEG Encoder, Key Generator, Media-Codec, MediaCodec, MMediaCodec, MovieCommander, MPCODEC, My Pass Generator, PCODEC, Perfect Codec, PowerCodec, PornPass Manager, PornMag Pass, PrivateVideo, QualityCodec, Silver Codec, SiteEntry, SiteTicket, SoftCodec, strCodec, Super Codec, TrueCodec, VideoAccess, VideoBox, VidCodecs, Video Access ActiveX Object, Video ActiveX Object, VideoCompressionCodec, VideoKeyCodec, VideosCodec, WinAntiSpyPro, WinMediaCodec, X Password Generator, X Password Manager, ZipCodec"
It's definately safe as i've used it several times and seen it reviewed to be the most effective.
http://siri.geekstogo.com/SmitfraudFix.php